Warthin’s Tumour

  • A Warthin’s Tumour, also known as Papillary Cystadenoma Lymphomatosum, is the second most common benign salivary gland tumour after a pleomorphic adenoma.1
  • It occurs almost exclusively in the parotid gland, can be bilateral in around 10% of patients, and is more commonly seen in smokers.

Pathologic Features

  • On microscopy, a Warthin’s Tumour is characterized by a bilayered oncocytic epithelium arranged in papillary structures, with or without cystic spaces.2
  • Beneath the oncocytic epithelium is a dense lymphoid stroma
  • This combination of a bilayered oncocytic epithelium and a lymphoid stroma is classic for a Warthin’s tumour.

Warthin's tumour histopathology

  1. Cardesa, Antonio, et al., eds. Pathology of the Head and Neck. Vol. 316. Berlin: Springer, 2006. 

  2. Handra-Luca A, Hang JF. Warthin tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/salivaryglandswarthin.html. Accessed September 29th, 2022. 

Last updated September 29, 2022